Lynch Syndrome & Inherited Cancer

Lynch syndrome genes

Mutations in the five genes listed below cause Lynch syndrome. Each gene is associated with different risks and guidelines. Learn more about each gene by clicking on the name.

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Lynch syndrome cancers

The most common cancers associated with Lynch syndrome are colorectal and endometrial cancer. Depending on the gene, Lynch syndrome may also increase the risk for other cancers, including:

​​​​Cancer risks and management guidelines vary by gene, so knowing which mutation you have is very important. A genetics expert can help you understand more about your genetic test results.

Does everyone with Lynch syndrome get cancer? 

Although the lifetime risk for cancer with Lynch syndrome is very high, not everyone with Lynch syndrome develops cancer. Following the guidelines for screening and prevention in people with Lynch syndrome increase the chances of preventing cancer or catching it at its earliest and most treatable stage. Because these guidelines vary by gene, it's important to know and follow the guidelines recommended for your specific mutation.

Lynch syndrome guidelines

Cancer risks and management guidelines are different for each Lynch syndrome gene. It's important to know which Lynch syndrome gene mutation you have. The name of your gene mutation will be listed on your genetic test results. Once you know your gene, you can view the risk-management guidelines for your gene by clicking on the link above. Speaking with a genetics expert can help ensure that you receive the most accurate and up-to-date information about options for managing your cancer risk. 

Can Lynch syndrome skip a generation?

Lynch syndrome mutations are passed down from parents to children, but they do not skip generations. Each person with Lynch syndrome has a 50% chance of passing their mutation on to each of their children. Children who did not inherit their parent's Lynch syndrome mutation cannot pass the mutation to their children. 

How common is Lynch syndrome?

About one in 280 people in the U.S. has a Lynch syndrome mutation, but many of them may not be aware of their increased risk for cancer. Genetic testing is the only way to know if you have Lynch syndrome.